Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Webb AJ, Patel N, Loukogeorgakis S, et al. Nutrients and nutraceuticals for the Management of High Normal Blood Pressure: an evidence-based consensus document. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.Ĭicero AFG, Grassi D, Tocci G, Galletti F, Borghi C, Ferri C. Besides suggesting more complex mechanisms, there is potential for maximising the clinical benefit of dietary nitrate and targeting isolated systolic hypertension.īlood pressure cytochrome p450 nitric oxide. Grapefruit juice enhanced beetroot juice's effect on lowering SBP and PP despite decreasing plasma. The taste score of Beet+GFJ was 1.4/10 points higher than Beet+H 2 O (P =. 006), as was salivary nitrite production (P =. Contrary to the hypothesis, plasma was lower with Active Beet+GFJ vs Active Beet+H 2 O (P =. Peak mean differences in SBP and PP were seen at T = 5 hours: -3.3 mmHg (95% confidence interval -6.43 to -0.15) and at T = 2.5 hours: -4.2 mmHg (95% CI -0.3 to -8.2), respectively. The addition of grapefruit juice to active beetroot juice lowered systolic BP (SBP): Active Beet+GFJ vs Active Beet+H 2 O (P =. We performed a randomized, placebo-controlled, 7-hour crossover study in 11 healthy volunteers, attending on 3 occasions, receiving: a 70-mL shot of active beetroot juice (Beet-It) and either (i) 250 mL grapefruit juice (Active Beet+GFJ), or (ii) 250 mL water (Buxton, Active Beet+H 2 O) or (iii) Placebo Beet+GFJ. We therefore hypothesized that grapefruit juice would enhance BP-lowering with beetroot juice by maintaining circulating. Grapefruit juice contains the CYP3A4 inhibitor furanocoumarin. Cytochrome P450-3A4 inhibition with troleandomycin prevents nitrite re-oxidation to nitrate in rodent liver. However, NO and nitrite are inactivated via reoxidation to nitrate, potentially limiting their activity. doi:10.3402/ nitrate from sources such as beetroot juice lowers blood pressure (BP) via the nitrate-nitrite-nitric oxide (NO) pathway. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in women, NHANES 2003-2008. Food Nutr Res. Potential of selected tropical fruit peels as dietary fiber in functional foods. International Journal of Food Properties. Wanlapa S, Wachirasiri K, Sithisam-ang D, Suwannatup T.(Nath P, Bouzayen M, Mattoo A, Pech J, eds.). Kanellis A, Manganaris G. Fruit Ripening.Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?. Grapefruit Juice and Some Drugs Don't Mix.Allergy to citrus juice. Clin Transl Allergy. Fruits for prevention and treatment of cardiovascular diseases. Nutrients. The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults. Metabolism. Dow CA, Going SB, Chow H-HS, Patil BS, Thomson CA. Potential mechanisms of action for vitamin C in cancer: Reviewing the evidence. Front Physiol. Lycopene and risk of prostate cancer: A systematic review and meta-analysis.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |